You don't hear much about Peyronie’s disease. But that's not too surprising when you consider that most men would rather not talk about “problems” below the belt. Peyronie's disease occurs when the tissue along the shaft of the penis thickens, causing erections to become increasingly curved and even painful. Applying iodine/DMSO to the thickened tissue twice a day over several months can soften it considerably and eventually allow for more normal functioning.